Elimination of Stabilised Hyaluronan from the Knee Joint in Healthy Men
Full list of Authors
Lindqvist U, Tolmachev V, Kairemo K, Astrom G, Jonsson E, Lundqvist H.
Full AMA reference
Lindqvist U., Tolmachev V., Kairemo K., Astrom G., Jonsson E., Lundqvist H. Elimination of Stabilised Hyaluronan from the Knee Joint in Healthy Men. Clin Pharmacokinet. 2002; 41 (8): 603-613.
Level-III clinical study: single center, uncontrolled study.
To investigate the elimination of stabilised hyaluronan following intra-articular injection into the knee joint of healthy men.
6 male subjects were injected with 3ml of radiolabeled DUROLANE into the knee joint. Radioactivity levels were then measured to assess how long it took for the DUROLANE to be eliminated from the human knee joint. Elimination of DUROLANE from the joint was described by three distinct phases, with half-times of 1.5 hours, 1.5 days and 4 weeks. Most likely, the last value reflects the true half-life of DUROLANE.