Efficacy and safety of a single intra-articular injection of nonanimal stabilized hyaluronic acid (NASHA) in patients with osteoarthritis of the knee
Full list of Authors
Altman RD, Åkermark C, Beaulieu AD, Schnitzer T.
Full AMA reference
Altman RD., Åkermark C., Beaulieu AD., Schnitzer T. Efficacy and safety of a single intra-articular injection of non-animal stabilized hyaluronic acid (NASHA) in patients with osteoarthritis of the knee. OsteoArthritis and Cartilage. 2004; 12: 642-649.
Level-I clinical study: multi centre, randomized, double blind and saline controlled.
This study was performed to investigate the safety and efficacy of single-injection NASHA compared with placebo in patients with OA of the knee.
346 patients with knee OA were randomized to a treatment group (172 DUROLANE, 174 saline). WOMAC and SF-36 scores were recorded at baseline and follow up visits at weeks 2, 6, 13 and 26 post injection. For the overall population, there were no statistically significant between-group differences in response rates for any efficacy parameters. In patients with OA confined to the knee (N=216), a greater response to
NASHA than placebo was observed at week 6 (P=0.025).