Intra-articular injection of non-animal stabilised hyaluronic acid (NASHA) for osteoarthritis of the hip: A pilot study
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Berg P, Olsson U.
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Berg P., Olsson U. Intra-articular injection of non-animal stabilised hyaluronic acid (NASHA) for osteoarthritis of the hip: A pilot study. Clin Exp Rheumatol. 2004; 22(3): 300-6.
Level-III clinical study: single centre, prospective open label, pilot study.
To assess the safety and potential efficacy of intra-articular non-animal stabilized hyaluronic acid (NASHA) in patients with hip OA.
31 patients with KL II-III osteoarthritis in the hip were treated with DUROLANE. Follow up was made at 2 weeks and 3 months post injection. A positive response was defined as a > or = 40% reduction in the WOMAC pain score from baseline, together with an absolute decrease of > or = 5 points. The response rate was 50% at 2 weeks and 54% at 3 months. In the extension population the response rates were 69% at 3 months and 44% at 6 months. There were 9 treatment related adverse events, the majority of which were arthralgia. The reaction was generally transient and all patients made a full recovery.