A randomized saline-controlled trial of NASHA hyaluronic acid for knee osteoarthritis
Full list of Authors
Arden NK, Åkermark C, Andersson M, Todman MG, Altman RD
Full AMA reference
Arden NK., Åkermark C., Andersson M., Todman MG., Altman RD. A randomized saline-controlled trial of NASHA hyaluronic acid for knee osteoarthritis. Current Medical Research & Opinion Vol. 2014; 30(2): 279–286.
Level-I clinical study: multi-centre, randomized, double-blind, saline-controlled.
A 6 week saline-controlled study to investigate the safety and efficacy of NASHA® in patients with mild–moderate structural OA confined to the study knee.
218 patients with KL grade II –III OA in a single knee were randomized into two treatment groups (DUROLANE 108, saline 110). No statistically significant difference in responder rate was found between the two groups at 6 weeks (NASHA: 30.6%; saline: 26.4%). A post-hoc subgroup analysis of patients without clinical effusion in the study knee at baseline showed a significantly higher (p=0.0084) 6 week responder rate with NASHA (NASHA: 40.6%; saline: 19.7%).