Reduction of arthritis associated knee pain through a single intraarticular injection of synthetic hyaluronic acid
Full list of Authors
Krocker D, Matziolis G, Tuischer J, Funk J, Tohtz S, Buttgereit F, Perka C.
Full AMA reference
Krocker D., Matziolis G., Tuischer J. et al. Reduction of arthritis associated knee pain through a single intra-articular injection of synthetic hyaluronic acid. Rheumatol. 2006; 65: 327–331.
Level-III clinical study: single centre, uncontrolled study.
To examine the efficacy of a single intra-articular injection of DUROLANE measured based on pain, functioning, and quality of life in patients with knee joint arthritis.
50 patients with KL grade I-III OA of the knee were treated with a single injection of DUROLANE. Patients were followed up at 2 and 24 weeks post injection. At all three visits, ROM, KOOS, EQ5D and VAS scores were recorded. Two weeks post injection there was an improvement in quality of life, 24 weeks after the injection there was a significant improvement (p<0.01) in all parameters.