How does DUROLANE work?

When you have osteoarthritis, the cartilage tissue in your joint begins to degenerate, and the hyaluronic acid content in the synovial fluid of the affected joint becomes diluted and breaks down faster, reducing its natural properties, which can further degrade cartilage tissue.⁸ Under arthritic conditions, the hyaluronic acid introduced as a viscosupplement causes a temporary increase in the normal hyaluronic acid level.

DUROLANE is a single-injection treatment designed to relieve osteoarthritis knee pain by supplementing the less healthy hyaluronic acid in an affected knee joint.¹⁸ Hyaluronic acid is a naturally occurring molecule that provides lubrication and cushioning in a normal, healthy joint. The hyaluronic acid in DUROLANE has the same composition as the hyaluronic acid a healthy body produces, so it is proven safe and biocompatible. In addition, hyaluronic acid in DUROLANE is produced with a unique stabilizing technology that helps resist hyaluronic acid degradation, for long-lasting relief of osteoarthritis symptoms.¹⁶

Your doctor will administer a single injection of DUROLANE directly into your knee joint.

Summary of Indications for Use

DUROLANE (3 mL): Symptomatic treatment of mild to moderate knee or hip osteoarthritis. In addition, DUROLANE has been approved for the symptomatic treatment associated with mild to moderate osteoarthritis pain in the ankle, shoulder, elbow, wrist, fingers, and toes.

DUROLANE (1 mL): Symptomatic treatment associated with mild to moderate osteoarthritis pain in the ankle, elbow, wrist, fingers, and toes.

Both DUROLANE and DUROLANE SJ are also indicated for pain following joint arthroscopy in the presence of osteoarthritis within three months of the procedure.

You should not use DUROLANE if you have infections or skin disease at the injection site. DUROLANE has not been tested in pregnant or lactating women, or children.

Risks can include transient pain, swelling and/or stiffness at the injection site. Full prescribing information can be found in product labeling.

DUROLANE, Bioventus and the Bioventus logo are registered trademarks of Bioventus LLC. NASHA is a registered trademark of Nestlé Skin Health S.A.

Patient information leaflet available here.

© 2019 Bioventus LLC.

^{*First introduced in the European Union in 2001.}

To learn more about DUROLANE or for contact information, please select your location to continue.

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